A point to be cautious about when combining SSRIs (Selective Serotonin Reuptake Inhibitors) and herbal medicine is the risk of serotonin syndrome. Western St. John's Wort (a Western herb used for depression) raises serotonin levels and is dangerous when taken with SSRIs, but traditional Korean herbal medicine ingredients do not contain this component. Herbal medicines that nourish both the mind and the spleen/stomach, as well as herbal ingredients that resolve phlegm and stabilize the mind, have minimal direct impact on serotonin levels and can be used in conjunction with SSRIs. Dongjedang strictly verifies the list of psychiatric medications currently being taken during consultations and prescribes selected ingredients that pose no risk of interaction. If the patient is taking SSRIs, we advise leaving a 1-2 hour interval to reduce competition for absorption, and also recommend consulting with the attending psychiatrist regarding dosage adjustments once symptoms stabilize. We strongly emphasize that SSRIs must never be discontinued arbitrarily.